On Tuesday 25 April 2006 01:01 pm, Laura Sanborn wrote:
> HeartGard, Sentinel, Interceptor, Revolution, and Proheart all contain
> macrocyclic lactone insecticides.
Thanks Laura, for pointing out the research on toxicity in collies for
milbemycin, with result being that it is has similar toxicity at similar
overdose levels (20X recommended dose) as ivermectin.
I didn't know that milbemycin is in the same class (macrocyclic lactones) as
avermectins nor that the toxicity concerns for collie-related breeds were
similar to ivermectin. That's really important to know.
Found it fascinating that this class of chemicals is derived from soil
I'm afraid of what we might find out about environmental effects down the
road, things are always more complicated than one single effect (just the
intended one), in an ecosystem. But there's never been anything more
effective against certain kinds of nasty mites on animals than the
avermectins. I haven't dealt with demodectic mange, can only imagine how
terrible that is. But I've dealt with ear mites in poor dropped off kittens,
and scaly leg mites in poultry. Before the avermectins, such mite elimination
was either not possible at all, or pretty hard on the animal. With
avermectins the cure is fast and painless (at least if the animal is not
affected with the MDR-1 gene... I don't know if cats and birds might also
have that type of mutation).