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Wed, 10 May 2006 10:05:42 +0200 |
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On Tue, 9 May 2006, David Harris wrote:
> Isodat 2.0 for chromatography peak detection/evaluation offers several
> background correction modes but I can find no explanation as to what they
> various modes actually do. Has anyone figured this out? I am particularly
> interested in understanding the mode ' dynamic BGD' and its parameter 'step
> width'
>
The algorithms are presented in
Ricci, P., Merrit, D.A., Freeman, K. H., Hayes, J. M. (1994).
Acqusition and processing of data for isotope-ratio-monitoring
mass spectrometry, Org Geochem, 21(6/7), 561-571.
From my experience choosing "Dynamic BGD" does not perform
particularly well and "Individual BGD" can cover virtually
every problem. If your BGD is grossly changing over time and
if you possibly feel its too high, I'd rather consider
additional purification of the samples.
--
Uli Flenker
Institute of Biochemistry
German Sport University Cologne
Carl-Diem-Weg 6
50933 Cologne
+49(0)221/4982-5060
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