I'm always suspicious when told it was 3 mos ago in NEJM (or somesuch); it
usually turns out to be in JAMA years ago--but we've all been through that.
And I think this is another case. Take a look at the following:
1: Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12903-10. Epub 2006 Aug 10.
Comment in:
Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12661-2.
Prenatal exposure to ultrasound waves impacts neuronal migration in mice.
Ang ES Jr, Gluncic V, Duque A, Schafer ME, Rakic P.
Department of Neurobiology and Kavli Institute for Neuroscience, Yale
Medical School, Sterling Hall of Medicine, Room C-318, 333 Cedar Street, New
Haven, CT 06510, USA.
Neurons of the cerebral neocortex in mammals, including humans, are
generated during fetal life in the proliferative zones and then migrate to
their final destinations by following an inside-to-outside sequence. The
present study examined the effect of ultrasound waves (USW) on neuronal
position within the embryonic cerebral cortex in mice. We used a single BrdU
injection to label neurons generated at embryonic day 16 and destined for
the superficial cortical layers. Our analysis of over 335 animals reveals
that, when exposed to USW for a total of 30 min or longer during the period
of their migration, a small but statistically significant number of neurons
fail to acquire their proper position and remain scattered within
inappropriate cortical layers and/or in the subjacent white matter. The
magnitude of dispersion of labeled neurons was variable but systematically
increased with duration of exposure to USW. These results call for a further
investigation in larger and slower-developing brains of non-human primates
and continued scrutiny of unnecessarily long prenatal ultrasound exposure.
PMID: 16901978 [PubMed - indexed for MEDLINE]
Lee Hover
Information Developers
Boonton Twp., NJ
-----Original Message-----
From: Medical Libraries Discussion List
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Sent: Friday, February 09, 2007 2:49 PM
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Subject: Re: question
Dear Colleagues,
Could anyone help in finding the following? One of my editors think there
was an article published 3 months ago in either Science or Nature Medicine
about ultrasound in pregnant mice has some effect on the fetus brain
development. I've searched PubMed Google, Science and Nature Medicine with
no luck. Any help with this will be greatly appreciated.
Marie Elias, MLS
Medical Librarian
The Medical Letter, Library
1000 Main Street
New Rochelle, NY 10801
Tel: 914-235-0500 Ext. 307 or 334
Fax: 914-235-5079
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