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https://www.nytimes.com/2020/01/31/science/neanderthal-dna-africa.html
Neanderthal Genes Hint at Much Earlier Human Migration From Africa

Modern humans may have left the continent as long 200,000 years ago, a new
analysis suggests.
[image: A Neanderthal fossil on view at the Natural History Museum in
London. A new genetic analysis revealed traces of Neanderthal DNA in all
living humans, including Africans, who were thought to have none.]
A Neanderthal fossil on view at the Natural History Museum in London. A new
genetic analysis revealed traces of Neanderthal DNA in all living humans,
including Africans, who were thought to have none.Credit...The Natural
History Museum/Alamy

[image: Carl Zimmer] <https://www.nytimes.com/by/carl-zimmer>

By Carl Zimmer <https://www.nytimes.com/by/carl-zimmer>
Jan. 31, 2020

In recent years, millions of people have been astonished, even thrilled, to
learn from those popular genetic tests that their DNA is laced with
Neanderthal genes.

Those genes were first discovered in 2010, in a study of Neanderthal
fossils. From DNA recovered from the bones, researchers deduced that modern
humans interbred with Neanderthals some 60,000 years ago, after leaving
Africa.

As a result, the genes of non-Africans today are 1 percent to 2 percent
Neanderthal. People of African ancestry, it was thought, have little to no
Neanderthal DNA.

Using a new method to analyze DNA, however, a team of scientists has found
evidence that significantly reshapes that narrative.

Their study, published on Thursday in the journal Cell, concludes that a
wave of modern humans departed Africa far earlier than had been known
<https://www.cell.com/cell/fulltext/S0092-8674(20)30059-3>: some 200,000
years ago.

These people interbred with Neanderthals, the new study suggests. As a
result, Neanderthals were already carrying genes from modern humans when
the next big migration from Africa occurred, about 140,000 years later.
The scientists also found evidence that people living somewhere in western
Eurasia moved back to Africa and interbred with people whose ancestors
never left. The new study suggests that all Africans have a substantially
greater amount of Neanderthal DNA than earlier estimates.

“The legacy of gene flow with Neanderthals likely exists in all modern
humans, highlighting our shared history,” the authors concluded.

“Overall, I find this a fantastic study,” said Omer Gokcumen, a geneticist
at the University at Buffalo, who was not involved in the research. The
research offers a view of human history “almost as a spider web of
interactions, rather than a tree with distinct branches.”

But while evidence has been building that modern humans left Africa in
waves, and that those migrations began much earlier than once thought, some
scientists disputed the evidence that people of African descent may be
carrying Neanderthal genes.

David Reich
<https://www.nytimes.com/2018/03/20/science/david-reich-human-migrations.html>,
a geneticist at Harvard Medical School, praised much of the study but said
he had doubts about how extensive the flow of DNA back to Africa could have
been. “It looks like this is a really weak signal,” he said of the data.

The ancestors of humans and Neanderthals lived about 600,000 years ago in
Africa. The Neanderthal lineage left the continent; the fossils of what we
describe as Neanderthals range from 200,000 years to 40,000 years in age,
and are found in Europe, the Near East and Siberia.

Despite their reputation as brutes, Neanderthals showed signs of remarkable
mental sophistication
<https://www.nytimes.com/2017/01/11/magazine/neanderthals-were-people-too.html>.
They were adept hunters
<https://www.nytimes.com/2017/09/07/science/neanderthals-tar-glue.html>,
and appear to have made ornaments as a form of self-expression
<https://www.nytimes.com/2018/02/22/science/neanderthals-cave-paintings-europe.html>
.
[image: A bone from a Neanderthal toe. The analysis found evidence for an
early migration from Africa, and a later return to the continent.]
A bone from a Neanderthal toe. The analysis found evidence for an early
migration from Africa, and a later return to the continent.Credit...Bence
Viola

Ten years ago, Dr. Reich and his colleagues gathered enough bits of DNA
from fossils to create the first rough draft of the Neanderthal genome
<https://science.sciencemag.org/content/328/5979/710>.

When the researchers compared it to the genomes of eight living people,
they found that the Neanderthal was a little more similar to the people of
Asian and European descent than to those of African heritage.

Roughly 60,000 years ago, the researchers argued, modern humans must have
expanded from Africa and interbred with Neanderthals. The hybrid
descendants passed their genes to later generations, who spread around the
globe.

That hypothesis has held up well over the past decade, as
paleoanthropologists have extracted more complete Neanderthal genomes from
other fossils
<https://www.nytimes.com/2013/12/19/science/toe-fossil-provides-complete-neanderthal-genome.html>
.

But Joshua Akey, a geneticist at Princeton University who carried out some
of these studies, grew dissatisfied with the methods used to look for
Neanderthal DNA in living people. The standard method was built on the
assumption that most Africans had no Neanderthal DNA at all.

Dr. Akey and his colleagues figured out a new method, which they call
IBDMix, that takes advantage of the fact that relatives share stretches of
matching DNA.

Siblings, for example, share many long, identical stretches of DNA. But
their children will have fewer identical segments, which will also be
shorter. Distantly related cousins will have tinier matching segments that
require sophisticated methods to uncover.

Dr. Akey and his colleagues figured out how to search the DNA of living
humans and remains of Neanderthals for these minuscule matching segments.
Then they pinpointed the segments that came from a relatively recent
ancestor — and therefore were a sign of interbreeding.

The scientists searched 2,504 genomes of living humans for segments that
matched those in a Neanderthal genome. When the scientists tallied up the
results, the results took Dr. Akey by surprise.

The human genome is detailed in units called base pairs, about 3 billion
such pairs in total. The scientists found that Europeans on average had 51
million base pairs that matched Neanderthal DNA, and East Asians had 55
million.

Dr. Akey’s previous research had indicated that East Asians carried far
more Neanderthal ancestry than did Europeans
<https://www.nytimes.com/2015/02/20/science/a-new-theory-on-how-neanderthal-dna-spread-in-asia.html>
.

Africans on average had 17 million base pairs that matched Neanderthal DNA
— far higher than predicted by the original models describing how humans
and Neanderthals interbred.

“That was just so completely opposite to my expectations,” said Dr. Akey.
“It took a while to convince ourselves that what we are finding with this
new approach was actually true*.*”

Looking at the size of these shared segments and how common they were
around the world, Dr. Akey and his colleagues realized that some were the
result of interbreeding very early in human history.

They concluded that a group of modern humans expanded out of Africa perhaps
200,000 years ago and interbred with Neanderthals. Those modern humans then
disappeared. But Neanderthals who lived after that disappearance inherited
some modern human DNA.

Other experts said the new study offered compelling support for earlier
hints for this ancient expansion. Last year, for example, a team of
scientists reported finding a modern human skull in Greece dating back over
210,000 years
<https://www.nytimes.com/2019/07/10/science/skull-neanderthal-human-europe-greece.html>
.

Other researchers discovered small fragments of DNA in Neanderthal fossils
that showed a striking similarity to modern human genes
<https://www.nytimes.com/2016/02/23/science/ancient-humans-may-have-left-a-genetic-mark-on-neanderthals.html>
.

Despite his hesitation over the analysis of African DNA, Dr. Reich said the
new findings do make a strong case that modern humans departed Africa much
earlier than thought.

“I was on the fence about that, but this paper makes me think it’s right,”
he said.

It’s possible that humans and Neanderthals interbred at other times, and
not just 200,000 years ago and again 60,000 years ago. But Dr. Akey said
that these two migrations accounted for the vast majority of mixed DNA in
the genomes of living humans and Neanderthal fossils.

In recent years, Dr. Reich and other researchers have found evidence that
ancient people from the Near East moved back into Africa in the past few
thousand years and spread their DNA to many African populations
<https://www.nytimes.com/2017/09/21/science/africa-dna-migration.html>.

Dr. Akey and his colleagues confirmed this migration, although their study
suggests that it may have taken place over a much longer period of time and
introduced much more DNA into populations across the continent.

Janet Kelso of the Max Planck Institute for Evolutionary Anthropology in
Leipzig, Germany, who was not involved in the study, found this conclusion
“quite convincing.”

The findings may allow researchers to begin pinpointing segments of
Neanderthal DNA in living Africans.

Sarah Tishkoff, a geneticist at the University of Pennsylvania, is doing
just that, using the new methods to look for Neanderthal DNA in more
Africans to test Dr. Akey’s hypothesis.

Still, she wonders how Neanderthal DNA could have spread between
populations scattered across the entire continent.

“I’m still trying to wrap my head around that,” she said.


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