I agree. Quotations should always be attributed, with organizational
affiliations and credentials if possible.
----Original Message Follows----
From: Martha Livingston <[log in to unmask]>
Reply-To: Science for the People Discussion List
<[log in to unmask]>
To: [log in to unmask]
Subject: Re: HPV is the major cause of cervical cancer
Date: Tue, 27 Feb 2007 11:48:57 -0500
Hard to debate with "a letter I just received." Who's it from?
>Nothing is ever as simple as it fears appears. For instance, here's a
>letter I just received:
>"Here are a couple of things that Merck told me: girls under 18 were only
>tracked for 18 months, so no they don't know the long term effects or the
>long term efficacy by my way of thinking. 9,700 women had cervical cancer
>last year, 3,700 died. Of those diagnosed, about 30% of them [1,100] had no
>known origin (cause) of the cervical cancer. That means they have no idea
>why these women got it and HPV was not present. Of the rest [2,600] some
>did indeed have an HPV causal relationship (no numbers for how many) but
>many had a causal relationship with other viruses. So in terms of numbers,
>HPV is a pretty weak case."
>Now, I wouldn't go so far as the writer above who says that HPV is a pretty
>weak case. There clearly is SOME sort of correlation. But, and this has not
>yet been discussed,
>1) how many people get genital warts (HPV) each year, and how many of those
>people get cervical cancer? and,
>2) how many cases of cervical cancer are there each year among people who
>do not have genital warts?
>At 07:59 AM 2/27/2007, you wrote:
>>This paper suggests that Vitamin C might have a therapeutic effect in
>>treating cervical cancer, although we would want to see clinical results
>>that it actually works in practice. If an effective vaccine is indeed
>>available, we would have few cervical cancer cases to treat in the first
>>On 2/27/07, Jonathan Campbell <<mailto:[log in to unmask]>[log in to unmask]> wrote:
>>Biophys Res Commun 2001 (Mar 30); 282 (2): 409–15
>>Reddy VG, Khanna N, Singh N
>>Department of Biochemistry, All India Institute of Medical Sciences, New
>>Human Papilloma Virus (HPV) is associated in most instances with cervical
>>cancer. The HPV oncoproteins target P53 protein for degradation, leading
>>to deregulation of cell cycle. We investigated whether stabilization of
>>P53 in cervical cancer cells, by downregulating HPV transcription would
>>restore the apoptotic ability of these cells. Our findings show that
>>vitamin C downregulates the redox sensitive transcription factor AP-1 and
>>decreases one of its transcription targets HPV E6, and stabilizes P53.
>>This was associated with an increase in Bax and decrease in Bcl-2 and
>>telomerase activity. Accumulation of P53 and its target gene bax then
>>sensitized HeLa cells to cell-cycle arrest, cell death/apoptosis induced
>>by cisplatin, and etoposide. Increasing drug sensitivity of cervical
>>carcinoma cells by stabilizing P53 using vitamin C is a novel approach and
>>has potential clinical relevance.
>>Contributing Correspondent, Science
>><mailto:[log in to unmask]>[log in to unmask]
Martha Livingston, Ph.D.
Associate Professor of Health and Society
SUNY College at Old Westbury
Old Westbury, New York 11568
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