No one special. That's why I didn't add her name.
Just someone on a list who decided to contact
Merck directly and ask for information.
At 11:48 AM 2/27/2007, you wrote:
>Hard to debate with "a letter I just received." Who's it from?
>>Nothing is ever as simple as it fears appears.
>>For instance, here's a letter I just received:
>>"Here are a couple of things that Merck told
>>me: girls under 18 were only tracked for 18
>>months, so no they don't know the long term
>>effects or the long term efficacy by my way of
>>thinking. 9,700 women had cervical cancer last
>>year, 3,700 died. Of those diagnosed, about 30%
>>of them [1,100] had no known origin (cause) of
>>the cervical cancer. That means they have no
>>idea why these women got it and HPV was not
>>present. Of the rest [2,600] some did indeed
>>have an HPV causal relationship (no numbers for
>>how many) but many had a causal relationship
>>with other viruses. So in terms of numbers, HPV is a pretty weak case."
>>Now, I wouldn't go so far as the writer above
>>who says that HPV is a pretty weak case. There
>>clearly is SOME sort of correlation. But, and this has not yet been discussed,
>>1) how many people get genital warts (HPV) each
>>year, and how many of those people get cervical cancer? and,
>>2) how many cases of cervical cancer are there
>>each year among people who do not have genital warts?
>>At 07:59 AM 2/27/2007, you wrote:
>>>This paper suggests that Vitamin C might have
>>>a therapeutic effect in treating cervical
>>>cancer, although we would want to see clinical
>>>results that it actually works in practice. If
>>>an effective vaccine is indeed available, we
>>>would have few cervical cancer cases to treat in the first place.
>>>On 2/27/07, Jonathan Campbell <<mailto:[log in to unmask]>[log in to unmask]> wrote:
>>>Biophys Res Commun 2001 (Mar 30); 282 (2): 40915
>>>Reddy VG, Khanna N, Singh N
>>>Department of Biochemistry, All India
>>>Institute of Medical Sciences, New Delhi, India
>>>Human Papilloma Virus (HPV) is associated in
>>>most instances with cervical cancer. The HPV
>>>oncoproteins target P53 protein for
>>>degradation, leading to deregulation of cell
>>>cycle. We investigated whether stabilization
>>>of P53 in cervical cancer cells, by
>>>downregulating HPV transcription would restore
>>>the apoptotic ability of these cells. Our
>>>findings show that vitamin C downregulates the
>>>redox sensitive transcription factor AP-1 and
>>>decreases one of its transcription targets HPV
>>>E6, and stabilizes P53. This was associated
>>>with an increase in Bax and decrease in Bcl-2
>>>and telomerase activity. Accumulation of P53
>>>and its target gene bax then sensitized HeLa
>>>cells to cell-cycle arrest, cell
>>>death/apoptosis induced by cisplatin, and
>>>etoposide. Increasing drug sensitivity of
>>>cervical carcinoma cells by stabilizing P53
>>>using vitamin C is a novel approach and has potential clinical relevance.
>>>Contributing Correspondent, Science
>>><mailto:[log in to unmask]>[log in to unmask]
>Martha Livingston, Ph.D.
>Associate Professor of Health and Society
>SUNY College at Old Westbury
>Old Westbury, New York 11568