You can buy from the companies that Harro suggested. The price of O-18 water fluctuates a lot as there is a worldwide mismatch between supply and demand, so shop around.
You will be able to buy 'sterile and pyrogen free' grade from these companies. However, I would advise you to talk to your hospital pharmacy at an early stage if you are going to use in patients. They may suggest to buy this grade but then to get additional testing for sterility and pyrogenicity from your hospital pharmacy department. If you buy 'sterile and pyrogen free' that is also certified GMP grade, you might not need additional testing. I was running a study which was suspended for nearly a year because we had not purchased through the hospital pharmacy, even though the grade was 'sterile and pyrogen free'. You'll also need to comply with whatever the hospital ethics committee want.
If you are not using in patients i.e. using in healthy volunteers, you might not need 'sterile and pyrogen free' grade. You can buy normal grade and filter through a 0.22 or 0.33 micron filter before use. Just make sure that you get approval from whatever is the appropriate ethics committee in your country e.g. University Ethics committee.
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UCL Institute of Child Health
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From: Nadine Rathmanner [mailto:[log in to unmask]]
Sent: 05 August 2013 09:55
Subject: DLW method
We would like to try the DLW (doubly labelled water) method from the IAEA. Now we realized that we would need DLW for medical purpose and human use - do you have an idea where to get this?