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MEDLIB-L  November 2013, Week 3

MEDLIB-L November 2013, Week 3

Subject:

Re: Help identifying a randomized trial - ? Intime

From:

"Vugrin, Margaret" <[log in to unmask]>

Reply-To:

Vugrin, Margaret

Date:

Wed, 20 Nov 2013 17:06:50 +0000

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (263 lines)

Guess the link doesnąt work  from Medscape



IN-TIME Sees Better Results, Fewer Deaths, With HF Home MonitoringShelley
Wood <http://www.medscape.com/author/shelley-wood>
September 01, 2013




EDITORS' RECOMMENDATIONS

* Home Monitoring for Heart Failure: About TIME
<http://www.medscape.com/viewarticle/812268>




Topic Alert
Receive an email from Medscape whenever new articles on this topic are
available.

*   
<https://profreg.medscape.com/px/updateTopicAlertSubscription.do?action=sub
scribeFromViewArticle&conceptId=64646&callback=?>Add Heart Failure to My
Topic Alert 
<https://profreg.medscape.com/px/updateTopicAlertSubscription.do?action=sub
scribeFromViewArticle&conceptId=64646&callback=?>




DRUG & REFERENCE INFORMATION

* Natriuretic Peptides in Congestive Heart Failure
<http://emedicine.medscape.com/article/761722-overview>
* Diuretics and Heart Failure
<http://emedicine.medscape.com/article/2145340-overview>
* Pediatric Congestive Heart Failure
<http://emedicine.medscape.com/article/2069746-overview>



AMSTERDAM ‹ Succeeding where others have failed, the IN-TIME
<http://www.clinicaltrials.gov/ct2/show/NCT00538356?term=IN-TIME&rank=1>
trial has demonstrated that wireless monitoring of implanted devices can
improve heart-failure outcomes.
Dr Gerhard Hindricks (University of Leipzig, Germany) presented IN-TIME to
the press here at the European Society of Cardiology (ESC) 2013 Congress
<http://www.medscape.com/viewcollection/32890> in advance of a hot-line
session later today.
"In-TIME is the first implant-based remote-monitoring randomized
controlled trial demonstrating significant benefits of implant-based home
monitoring for patients with advanced heart failure," Hindricks said.
Indeed, other small studies of heart-failure monitoring have been mixed,
and in two major randomized trials of HF telemedicine came up
empty-handed, prompting one expert to suggest these efforts should be
abandoned.
Just in Time?
All of the devices studied in IN-TIME were made by Biotronik and included
defibrillating cardiac resynchronization therapy (CRT-Ds) devices (58% of
patients) and implantable cardioverter defibrillators (ICDs) (42% of
patients). Patients were also equipped with "Cardio Messenger" systems for
their homes that relayed the data from their implants to a central
monitoring location.
A total of 716 patients were randomized to either home monitoring or a
control group with standard HF care; 82 patients (30 in the
home-monitoring group) terminated the study early due to deaths,
withdrawal of consent, loss to follow-up, or other reasons.
At 12 months, significantly fewer patients in the home-monitoring group
had reached the primary end point, worsening by modified Packer score (a
composite of mortality, overnight hospitalization for worsened HF, and
NYHA class global self-assessment). Moreover, fewer home-monitoring
patients died of any cause over the study period.
Outcomes With Home Monitoring vs Standard Care
End pointHome monitoring (%)Standard care (%)pWorsened HF, by modified
Packer score18.927.5<0.05All-cause mortality3.48.7<0.012
Asked why his study succeeded where others have not, Hindricks called the
Biotronik system "the most advanced implant-based telemonitoring
platform," with studies showing that the "chain of information with this
platform works very, very well.
"All the patient has to do after the implant has been done is plug in the
Cardio Messenger, and from that moment on--and this is really
important--everything works very automatically. Automatic detection of the
signals, automatic transmission--the patient does nothing. This is one of
the differences with other telemonitoring applications. Whenever you
involve patients, the likelihood that the chain of information, which is
crucial, doesn't work appropriately is very, very high."
Commenting on the study for heartwire , Dr Mariell Jessup (University of
Pennsylvania, Philadelphia) also highlighted the lack of patient
involvement.
"I think probably the difference in this trial is that the patients didn't
have to do anything special," she said. "They were having ongoing
monitoring, whether they wanted it or not. And we'll have to understand
more what components of that really translated into being such a
beneficial outcome, what kinds of interventions were made, did this make
people feel better, were there more trips to the hospital? We don't have
all that data."
To heartwire , Hindricks said that the results from IN-TIME would be easy
to translate to individual clinics, because of the highly automated nature
of the process. "We have more than 1000 patients at Heart Center Leipzig
using home monitoring, we have specially trained nursing staff who go to
the website and analyze the patients, the patients are in electronic
files, you don't see the patients without events, and you set the event
triggers according to study protocol or according to the individual needs
or requirements of the patients."
When a patient has an event that warrants further investigation, these are
flagged in the morning, and the physician can instigate follow-up. "It is
not that difficult. . . . It can be easily copied."
Hindricks disclosed receiving study grants, educational grants, and
honoraria from Biotronik.



* Comment



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Commenting is limited to medical professionals. To comment please Log-in
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dy5tZWRzY2FwZS5jb20vdmlld2FydGljbGUvODEwMzA5>.Commenting is moderated. See
our Terms of Use <http://www.medscape.com/public/termsofuse>.








~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~



Margaret Vugrin, MSLS, AHIP
Reference Librarian
Texas Tech University Health Sciences Library
3601 4th, MS7781
Lubbock, TX 79430

 <mailto:[log in to unmask]>[log in to unmask]
P 806-743-2241
F 806-743-2218




~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
If you need reference assistance please send an email to
[log in to unmask]
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

"Privacy/Confidentiality Notice: This message, including any attachments,
is for the sole use of the intended recipient(s) and may contain
confidential and privileged information. Any unauthorized review, use
disclosure or distribution is strictly prohibited. If you are not the
intended recipient, please contact the sender by reply email and destroy
all copies of the original message."







On 11/20/2013, 10:25 AM, "Vugrin, Margaret" <[log in to unmask]>
wrote:

>What about:  
>http://cp.mcafee.com/d/5fHCN8e3zqbbP1EVso7czztPqqb2bzxEVd7bXNJd5x5MtuVEVpd
>FEI8Ke6zAQsLCzASzuXzNEVsKYUrlS97o_fzbp6cE0GsSOtbtW3pKsSOtbtW3pKXOvSujvW_fT
>jd7aafnKnjhusVVd-WqvbnhIyCGyyDOEuvkzaT0QSyrhdTVeZXTLuZXCXCM0iLEkJGTYLxCnCd
>zelz_NV6XdPhOrGoxYiWLE7O85PM2GX4zIvC0kKpr8NB00E1pPr9QI0kLW3oafBivdCluZ1ISU
>Nt4S2_id40nYZoQgig-4VeBFg8Cy3jh17o8llAauwq89NBFVEwbCy0Aq80S4Va-rKrPHKV
>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
>
>
>
>Margaret Vugrin, MSLS, AHIP
>Reference Librarian
>Texas Tech University Health Sciences Library
>3601 4th, MS7781
>Lubbock, TX 79430
>
> <mailto:[log in to unmask]>[log in to unmask]
>P 806-743-2241
>F 806-743-2218
>
>
>
>
>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
>If you need reference assistance please send an email to
>[log in to unmask]
>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
>
>"Privacy/Confidentiality Notice: This message, including any attachments,
>is for the sole use of the intended recipient(s) and may contain
>confidential and privileged information. Any unauthorized review, use
>disclosure or distribution is strictly prohibited. If you are not the
>intended recipient, please contact the sender by reply email and destroy
>all copies of the original message."
>
>
>
>
>
>
>
>On 11/20/2013, 10:22 AM, "Lisa McCormick" <[log in to unmask]> wrote:
>
>>Dear Colleagues, a customer provided scant information for me to locate
>>articles on a randomized controlled trial conducted in Europe related to
>>"wireless medicine" or m-health.  I searched Clinical Trials.gov using
>>wireless & mhealth; I searched PubMed with variations of "Intime" and
>>searched on randomized controlled trials and remote monitoring, etc.
>>
>> 
>>
>>My hope is that one of you might recognize "Intime" and help me connect
>>it to the correct spelling or acronym.
>>
>> 
>>
>>Kind regards,
>>
>> 
>>
>>Lisa McCormick, MSLS, AHIP
>>
>>Health Sciences Library
>>
>>The Jewish Hospital
>>
>>llmccormickathealth-partners.org
>> 		 	   		  

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October 2006, Week 1
September 2006, Week 5
September 2006, Week 4
September 2006, Week 3
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September 2006, Week 1
August 2006, Week 5
August 2006, Week 4
August 2006, Week 3
August 2006, Week 2
August 2006, Week 1
July 2006, Week 5
July 2006, Week 4
July 2006, Week 3
July 2006, Week 2
July 2006, Week 1
June 2006, Week 5
June 2006, Week 4
June 2006, Week 3
June 2006, Week 2
June 2006, Week 1
May 2006, Week 5
May 2006, Week 4
May 2006, Week 3
May 2006, Week 2
May 2006, Week 1
April 2006, Week 4
April 2006, Week 3
April 2006, Week 2
April 2006, Week 1
March 2006, Week 5
March 2006, Week 4
March 2006, Week 3
March 2006, Week 2
March 2006, Week 1
February 2006, Week 4
February 2006, Week 3
February 2006, Week 2
February 2006, Week 1
January 2006, Week 5
January 2006, Week 4
January 2006, Week 3
January 2006, Week 2
January 2006, Week 1
December 2005, Week 5
December 2005, Week 4
December 2005, Week 3
December 2005, Week 2
December 2005, Week 1
November 2005, Week 5
November 2005, Week 4
November 2005, Week 3
November 2005, Week 2
November 2005, Week 1
October 2005, Week 5
October 2005, Week 4
October 2005, Week 3
October 2005, Week 2
October 2005, Week 1
September 2005, Week 5
September 2005, Week 4
September 2005, Week 3
September 2005, Week 2
September 2005, Week 1
August 2005, Week 5
August 2005, Week 4
August 2005, Week 3
August 2005, Week 2
August 2005, Week 1
July 2005, Week 5
July 2005, Week 4
July 2005, Week 3
July 2005, Week 2
July 2005, Week 1
June 2005, Week 5
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June 2005, Week 2
June 2005, Week 1
May 2005, Week 5
May 2005, Week 4
May 2005, Week 3
May 2005, Week 2
May 2005, Week 1
April 2005, Week 5
April 2005, Week 4
April 2005, Week 3
April 2005, Week 2
April 2005, Week 1
March 2005, Week 5
March 2005, Week 4
March 2005, Week 3
March 2005, Week 2
March 2005, Week 1
February 2005, Week 4
February 2005, Week 3
February 2005, Week 2
February 2005, Week 1
January 2005, Week 5
January 2005, Week 4
January 2005, Week 3
January 2005, Week 2
January 2005, Week 1
December 2004, Week 5
December 2004, Week 4
December 2004, Week 3
December 2004, Week 2
December 2004, Week 1
November 2004, Week 5
November 2004, Week 4
November 2004, Week 3
November 2004, Week 2
November 2004, Week 1
October 2004, Week 5
October 2004, Week 4
October 2004, Week 3
October 2004, Week 2
October 2004, Week 1
September 2004, Week 5
September 2004, Week 4
September 2004, Week 3
September 2004, Week 2
September 2004, Week 1
August 2004, Week 5
August 2004, Week 4
August 2004, Week 3
August 2004, Week 2
August 2004, Week 1
July 2004, Week 5
July 2004, Week 4
July 2004, Week 3
July 2004, Week 2
July 2004, Week 1
June 2004, Week 5
June 2004, Week 4
June 2004, Week 3
June 2004, Week 2
June 2004, Week 1
May 2004, Week 4
May 2004, Week 3
May 2004, Week 2
May 2004, Week 1
April 2004, Week 5
April 2004, Week 4
April 2004, Week 3
April 2004, Week 2
April 2004, Week 1
March 2004, Week 5
March 2004, Week 4
March 2004, Week 3
March 2004, Week 2
March 2004, Week 1
February 2004, Week 5
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February 2004, Week 3
February 2004, Week 2
February 2004, Week 1
January 2004, Week 5
January 2004, Week 4
January 2004, Week 3
January 2004, Week 2
January 2004, Week 1
December 2003, Week 5
December 2003, Week 4
December 2003, Week 3
December 2003, Week 2
December 2003, Week 1
November 2003, Week 5
November 2003, Week 4
November 2003, Week 3
November 2003, Week 2
November 2003, Week 1
October 2003, Week 5
October 2003, Week 4
October 2003, Week 3
October 2003, Week 2
October 2003, Week 1
September 2003, Week 5
September 2003, Week 4
September 2003, Week 3
September 2003, Week 2
September 2003, Week 1
August 2003, Week 5
August 2003, Week 4
August 2003, Week 3
August 2003, Week 2
August 2003, Week 1
July 2003, Week 5
July 2003, Week 4
July 2003, Week 3
July 2003, Week 2
July 2003, Week 1
June 2003, Week 5
June 2003, Week 4
June 2003, Week 3
June 2003, Week 2
June 2003, Week 1
May 2003, Week 5
May 2003, Week 4
May 2003, Week 3
May 2003, Week 2
May 2003, Week 1
April 2003, Week 5
April 2003, Week 4
April 2003, Week 3
April 2003, Week 2
April 2003, Week 1
March 2003, Week 5
March 2003, Week 4
March 2003, Week 3
March 2003, Week 2
March 2003, Week 1
February 2003, Week 4
February 2003, Week 3
February 2003, Week 2
February 2003, Week 1
January 2003, Week 5
January 2003, Week 4
January 2003, Week 3
January 2003, Week 2
January 2003, Week 1
December 2002, Week 5
December 2002, Week 4
December 2002, Week 3
December 2002, Week 2
December 2002, Week 1
November 2002, Week 5
November 2002, Week 4
November 2002, Week 3
November 2002, Week 2
November 2002, Week 1
October 2002, Week 5
October 2002, Week 4
October 2002, Week 3
October 2002, Week 2
October 2002, Week 1
September 2002, Week 5
September 2002, Week 4
September 2002, Week 3
September 2002, Week 2
September 2002, Week 1
August 2002, Week 5
August 2002, Week 4
August 2002, Week 3
August 2002, Week 2
August 2002, Week 1
July 2002, Week 5
July 2002, Week 4
July 2002, Week 3
July 2002, Week 2
July 2002, Week 1
June 2002, Week 5
June 2002, Week 4
June 2002, Week 3
June 2002, Week 2
June 2002, Week 1
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May 2002, Week 3
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April 2002, Week 5
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April 2002, Week 3
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April 2002, Week 1
March 2002, Week 5
March 2002, Week 4
March 2002, Week 3
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February 2002, Week 4
February 2002, Week 3
February 2002, Week 2
February 2002, Week 1
January 2002, Week 5
January 2002, Week 4
January 2002, Week 3
January 2002, Week 2
January 2002, Week 1
December 2001, Week 5
December 2001, Week 4
December 2001, Week 3
December 2001, Week 2
December 2001, Week 1
November 2001, Week 5
November 2001, Week 4
November 2001, Week 3
November 2001, Week 2
November 2001, Week 1
October 2001, Week 5
October 2001, Week 4
October 2001, Week 3
October 2001, Week 2
October 2001, Week 1
September 2001, Week 5
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September 2001, Week 3
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September 2001, Week 1
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August 2001, Week 4
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July 2001, Week 1
June 2001, Week 5
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June 2001, Week 3
June 2001, Week 2
June 2001, Week 1
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May 2001, Week 4
May 2001, Week 3
May 2001, Week 2
May 2001, Week 1
April 2001, Week 5
April 2001, Week 4
April 2001, Week 3
April 2001, Week 2
April 2001, Week 1
March 2001, Week 5
March 2001, Week 4
March 2001, Week 3
March 2001, Week 2
March 2001, Week 1
February 2001, Week 4
February 2001, Week 3
February 2001, Week 2
February 2001, Week 1
January 2001, Week 5
January 2001, Week 4
January 2001, Week 3
January 2001, Week 2
January 2001, Week 1
December 2000, Week 5
December 2000, Week 4
December 2000, Week 3
December 2000, Week 2
December 2000, Week 1
November 2000, Week 5
November 2000, Week 4
November 2000, Week 3
November 2000, Week 2
November 2000, Week 1
October 2000, Week 5
October 2000, Week 4
October 2000, Week 3
October 2000, Week 2
October 2000, Week 1
September 2000, Week 5
September 2000, Week 4
September 2000, Week 3
September 2000, Week 2
September 2000, Week 1
August 2000, Week 5
August 2000, Week 4
August 2000, Week 3
August 2000, Week 2
August 2000, Week 1
July 2000, Week 5
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July 2000, Week 3
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July 2000, Week 1
June 2000, Week 5
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May 2000, Week 1
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April 2000, Week 3
April 2000, Week 2
April 2000, Week 1
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March 2000, Week 3
March 2000, Week 2
March 2000, Week 1
February 2000, Week 5
February 2000, Week 4
February 2000, Week 3
February 2000, Week 2
February 2000, Week 1
January 2000, Week 5
January 2000, Week 4
January 2000, Week 3
January 2000, Week 2
January 2000, Week 1
December 1999, Week 5
December 1999, Week 4
December 1999, Week 3
December 1999, Week 2
December 1999, Week 1
November 1999, Week 5
November 1999, Week 4
November 1999, Week 3
November 1999, Week 2
November 1999, Week 1
October 1999, Week 5
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October 1999, Week 3
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October 1999, Week 1
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May 1999, Week 1
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April 1999, Week 3
April 1999, Week 2
April 1999, Week 1
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March 1999, Week 3
March 1999, Week 2
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February 1999, Week 3
February 1999, Week 2
February 1999, Week 1
January 1999, Week 5
January 1999, Week 4
January 1999, Week 3
January 1999, Week 2
January 1999, Week 1
December 1998, Week 5
December 1998, Week 4
December 1998, Week 3
December 1998, Week 2
December 1998, Week 1
November 1998, Week 5
November 1998, Week 4
November 1998, Week 3
November 1998, Week 2
November 1998, Week 1
October 1998, Week 5
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October 1998, Week 3
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October 1998, Week 1
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April 1998, Week 5
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April 1998, Week 1
March 1998, Week 5
March 1998, Week 4
March 1998, Week 3
March 1998, Week 2
March 1998, Week 1
February 1998, Week 4
February 1998, Week 3
February 1998, Week 2
February 1998, Week 1
January 1998, Week 5
January 1998, Week 4
January 1998, Week 3
January 1998, Week 2
January 1998, Week 1
December 1997, Week 5
December 1997, Week 4
December 1997, Week 3
December 1997, Week 2
December 1997, Week 1
November 1997, Week 5
November 1997, Week 4
November 1997, Week 3
November 1997, Week 2
November 1997, Week 1
October 1997, Week 5
October 1997, Week 4
October 1997, Week 3
October 1997, Week 2
October 1997, Week 1
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September 1997, Week 2
September 1997, Week 1
August 1997, Week 5
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August 1997, Week 3
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August 1997, Week 1
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July 1997, Week 1
June 1997, Week 5
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June 1997, Week 3
June 1997, Week 2
June 1997, Week 1
May 1997, Week 5
May 1997, Week 4
May 1997, Week 3
May 1997, Week 2
May 1997, Week 1
April 1997, Week 5
April 1997, Week 4
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April 1997, Week 1
March 1997, Week 5
March 1997, Week 4
March 1997, Week 3
March 1997, Week 2
March 1997, Week 1
February 1997, Week 4
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February 1997, Week 2
February 1997, Week 1
January 1997, Week 5
January 1997, Week 4
January 1997, Week 3
January 1997, Week 2
January 1997, Week 1
December 1996, Week 5
December 1996, Week 4
December 1996, Week 3
December 1996, Week 2
December 1996, Week 1
November 1996, Week 5
November 1996, Week 4
November 1996, Week 3
November 1996, Week 2
November 1996, Week 1
October 1996, Week 5
October 1996, Week 4
October 1996, Week 3
October 1996, Week 2
October 1996, Week 1
September 1996, Week 5
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September 1996, Week 1
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May 1996, Week 1
April 1996, Week 5
April 1996, Week 4
April 1996, Week 3
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April 1996, Week 1
March 1996, Week 5
March 1996, Week 4
March 1996, Week 3
March 1996, Week 2
March 1996, Week 1
February 1996, Week 5
February 1996, Week 4
February 1996, Week 3
February 1996, Week 2
February 1996, Week 1
January 1996, Week 5
January 1996, Week 4
January 1996, Week 3
January 1996, Week 2
January 1996, Week 1
December 1995, Week 5
December 1995, Week 4
December 1995, Week 3
December 1995, Week 2
December 1995, Week 1
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April 1995, Week 5
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April 1995, Week 1
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February 1995, Week 1
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December 1994, Week 5
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