I've used Optison with success during echocardiography, but have not tried
it for any vascular work. I saw a demonstration at a conference once,
where the contrast agent could be visualized in the carotid arteries, but
as far as I know, it is not approved for vascular applications, although
there has been some experimentation with it. It only stays in the heart
for a matter of about 3 minutes before the bubbles break up and it is
exhaled through the lungs. I've never seen a patient experience any side
effects with it. Because it contains albumin, it is contraindicated in
those patients with known allergies to blood or blood products. It will be
interesting to hear if you see it at all in the renals.....its hard to
imagine that a full renal interrogation could be obtained in a matter of
minutes! Let us know if you use it and what happened!
> From: Michel Comeaux <[log in to unmask]>
> To: [log in to unmask]
> Subject: use of drug optison
> Date: Thursday, May 06, 1999 6:00 PM
> I have been asked by a cardiologist to perform a renal artery study on a
> patient that he says is large and has poor renal functions therefore
> undergo angiography. He would like for me to give the patient the drug
> Optison (human albumin microspheres) if I am unable to adequately
> the renal arteries. According to the literature, this is successfully
> during echocardiography when the outline of the heart is not adequately
> visualized. It is excreted through the lungs rather than the kidneys.
> literature does not state that it works the same for visualization of the
> Does anyone have any experience with or knowledge of this drug?
> Thank you.
> Michel Comeaux, RN, RVT, RDMS
> Noninvasive Vascular Lab
> New Iberia, La.