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Dear friends,

I ran a search for sustained release preparations of the anti-diabetic
agent metformin on Pubmed.
Sustained release preparations mapped to "delayed action preparations" as a
MESH term. On combination with metfromin, I was able to select two studies
whcih were relevant to us. The person who wanted the information ran an
independednt search on Medscape medline and through a combination of text
terms found an additional reference on the same topic.

I checked back in Pubmed, and found that even though the reference found by
my colleague was  on a sustained release preparation of metfromin, the
indexing terms did not include : "delayed action preparations". !!!!!!!!!

Quite obviously  a crucial reference had been left out.
Does this happen often ? If I am running a search on Pubmed, would it be
safer to also try out text word options. ?? In this particular case, maybe
I should have tried out "slow relase" and" controlled release" also as text
terms ??

I am enclosing the actual reference too........

UI  - 99236270
AU  - Yuen KH
AU  - Peh KK
AU  - Tan BL
TI  - Relating in vitro/in vivo data of two controlled-release metformin
      formulations.
LA  - Eng
MH  - Adult
MH  - Chemistry, Pharmaceutical
MH  - Cross-Over Studies
MH  - Human
MH  - Hypoglycemic Agents/*administration & dosage
MH  - Male
MH  - Metformin/*administration & dosage/chemistry/pharmacokinetics
MH  - Middle Age
MH  - Solubility
RN  - 0 (Hypoglycemic Agents)
RN  - 657-24-9 (Metformin)
PT  - CLINICAL TRIAL
PT  - JOURNAL ARTICLE
PT  - RANDOMIZED CONTROLLED TRIAL
DA  - 19990610
DP  - 1999 May
IS  - 0363-9045
TA  - Drug Dev Ind Pharm
PG  - 613-8
SB  - M
CY  - UNITED STATES
IP  - 5
VI  - 25
JC  - C8D
AA  - Author
EM  - 199908
AB  - This study was conducted to compare the bioavailability of two
      controlled-release metformin preparations (Diabetmin Retard and
Glucophage
      Retard) and also to correlate the in vitro and in vivo data obtained
with
      the two preparations. Twelve healthy volunteers participated in the
study,
      conducted according to a completely randomized, two-way crossover
design.
      The preparations were compared using area under the plasma
      concentration-time curve AUC0-infinity, time to reach peak plasma
      concentration Tmax, and peak plasma concentration Cmax, while
correlation
      was determined between in vitro release and in vivo absorption.
Diabetmin
      Retard demonstrated a slower rate of in vitro release, but a faster rate
      of in vivo absorption than Glucophage Retard. However, the in vivo
      absorption of both products was found to be slower than that of drug
      released in vitro. A satisfactory relationship could be established
      between the in vitro and in vivo results, but there was no rank order
      correlation. No statistically significant difference was observed
between
      the two preparations in the parameters AUC0-infinity and Cmax.
However, a
      slight but statistically significant difference was observed between the
      Tmax values, but it may not be therapeutically significant. Moreover,
the
      90% confidence interval for the ratio of the logarithmic transformed
      AUC0-infinity values, as well as the logarithmic transformed Cmax
values,
      of Diabetmin Retard over those of Glucophage Retard was within the
      acceptance criteria of 0.80-1.25.
AD  - School of Pharmaceutical Sciences, University of Science, Malaysia.
      [log in to unmask]
PMID- 0010219530
EDAT- 1999/04/29 02:03
MHDA- 1999/04/29 02:03
SO  - Drug Dev Ind Pharm 1999 May;25(5):613-8



And i would apprecaite some comments and feedback ..
Sudha Kannan
Manager, Medical Information Services
Wockhardt Ltd.
Wockhardt Towers
Bandra Kurla Complex
Bandra (East)
Mumbai-400051
India
Phone: 91-22-6534444
Fax: 91-22-6534242