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I've checked PubMed, Google, with daptomycin and prophylaxis, daptomycin and clinical trials. The requestor has checked Medscape. What I'm finding is daptomycin usage for "Complicated skin/structure infections that are a common complication of surgery, foot ulcers, and burns", for which it is FDA approved. The requestor is interested in its use prophylactically. Any other search strategy suggestions, other than the FDA site, that I might check before concluding that nothing has been published concerning prophylactic usage? Thanks for any and all help. Cindy Cindy Macko Reference Library St. Mary Medical Center Community Healthcare System 1500 S. Lake Park Ave. Hobart IN 46342 219-947-6230 219-947-6331 (fax) [log in to unmask] ____________________________________ This message and attachment(s), if any, is intended for the sole use of the individual and/or entity to which it is addressed, and may contain information that is privileged, confidential and prohibited from disclosure under applicable law. If you are not the addressee, or authorized to receive this on behalf of the addressee, you are hereby notified that you may not use, copy, disclose or distribute to anyone this message or any part thereof. If you have received this in error, please immediately advise the sender by e-mail and delete this information and all attachments from your computer and network. Thank you. ____________________________________