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I agree.  Quotations should always be attributed, with organizational 
affiliations and credentials if possible.

----Original Message Follows----
From: Martha Livingston <[log in to unmask]>
Reply-To: Science for the People Discussion List              
<[log in to unmask]>
To: [log in to unmask]
Subject: Re: HPV is the major cause of cervical cancer
Date: Tue, 27 Feb 2007 11:48:57 -0500

Hard to debate with "a letter I just received."  Who's it from?



>Nothing is ever as simple as it fears appears. For instance, here's a 
>letter I just received:
>
>"Here are a couple of things that Merck told me: girls under 18 were only 
>tracked for 18 months, so no they don't know the long term effects or the 
>long term efficacy by my way of thinking. 9,700 women had cervical cancer 
>last year, 3,700 died. Of those diagnosed, about 30% of them [1,100] had no 
>known origin (cause) of the cervical cancer. That means they have no idea 
>why these women got it and HPV was not present. Of the rest [2,600] some 
>did indeed have an HPV causal relationship (no numbers for how many) but 
>many had a causal relationship with other viruses. So in terms of numbers, 
>HPV is a pretty weak case."
>
>Now, I wouldn't go so far as the writer above who says that HPV is a pretty 
>weak case. There clearly is SOME sort of correlation. But, and this has not 
>yet been discussed,
>
>1) how many people get genital warts (HPV) each year, and how many of those 
>people get cervical cancer? and,
>
>2) how many cases of cervical cancer are there each year among people who 
>do not have genital warts?
>
>
>Mitchel Cohen
>
>
>At 07:59 AM 2/27/2007, you wrote:
>>This paper suggests that Vitamin C might have a therapeutic effect in 
>>treating cervical cancer, although we would want to see clinical results 
>>that it actually works in practice. If an effective vaccine is indeed 
>>available, we would have few cervical cancer cases to treat in the first 
>>place.
>>
>>MB
>>
>>On 2/27/07, Jonathan Campbell <<mailto:[log in to unmask]>[log in to unmask]> wrote:
>>FROM: 
>><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11401473&dopt=Abstract>Biochem 
>>Biophys Res Commun 2001 (Mar 30);   282 (2): 409–15
>>
>>Reddy VG, Khanna N, Singh N
>>
>>Department of Biochemistry, All India Institute of Medical Sciences, New 
>>Delhi, India
>>
>>Human Papilloma Virus (HPV) is associated in most instances with cervical 
>>cancer. The HPV oncoproteins target P53 protein for degradation, leading 
>>to deregulation of cell cycle. We investigated whether stabilization of 
>>P53 in cervical cancer cells, by downregulating HPV transcription would 
>>restore the apoptotic ability of these cells. Our findings show that 
>>vitamin C downregulates the redox sensitive transcription factor AP-1 and 
>>decreases one of its transcription targets HPV E6, and stabilizes P53. 
>>This was associated with an increase in Bax and decrease in Bcl-2 and 
>>telomerase activity. Accumulation of P53 and its target gene bax then 
>>sensitized HeLa cells to cell-cycle arrest, cell death/apoptosis induced 
>>by cisplatin, and etoposide. Increasing drug sensitivity of cervical 
>>carcinoma cells by stabilizing P53 using vitamin C is a novel approach and 
>>has potential clinical relevance.
>>
>>
>>
>>
>>--
>><http://www.michaelbalter.com>www.michaelbalter.com
>>
>>******************************************
>>Michael Balter
>>Contributing Correspondent, Science
>><mailto:[log in to unmask]>[log in to unmask]
>>******************************************

--
Martha Livingston, Ph.D.
Associate Professor of Health and Society
SUNY College at Old Westbury
Box 210
Old Westbury, New York 11568
(516) 876-2748

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