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Hard to debate with "a letter I just received."  Who's it from?



>Nothing is ever as simple as it fears appears. 
>For instance, here's a letter I just received:
>
>"Here are a couple of things that Merck told me: 
>girls under 18 were only tracked for 18 months, 
>so no they don't know the long term effects or 
>the long term efficacy by my way of thinking. 
>9,700 women had cervical cancer last year, 3,700 
>died. Of those diagnosed, about 30% of them 
>[1,100] had no known origin (cause) of the 
>cervical cancer. That means they have no idea 
>why these women got it and HPV was not present. 
>Of the rest [2,600] some did indeed have an HPV 
>causal relationship (no numbers for how many) 
>but many had a causal relationship with other 
>viruses. So in terms of numbers, HPV is a pretty 
>weak case."
>
>Now, I wouldn't go so far as the writer above 
>who says that HPV is a pretty weak case. There 
>clearly is SOME sort of correlation. But, and 
>this has not yet been discussed,
>
>1) how many people get genital warts (HPV) each 
>year, and how many of those people get cervical 
>cancer? and,
>
>2) how many cases of cervical cancer are there 
>each year among people who do not have genital 
>warts?
>
>
>Mitchel Cohen
>
>
>At 07:59 AM 2/27/2007, you wrote:
>>This paper suggests that Vitamin C might have a 
>>therapeutic effect in treating cervical cancer, 
>>although we would want to see clinical results 
>>that it actually works in practice. If an 
>>effective vaccine is indeed available, we would 
>>have few cervical cancer cases to treat in the 
>>first place.
>>
>>MB
>>
>>On 2/27/07, Jonathan Campbell <<mailto:[log in to unmask]>[log in to unmask]> wrote:
>>FROM: 
>><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11401473&dopt=Abstract>Biochem 
>>Biophys Res Commun 2001 (Mar 30);   282 (2): 
>>40915
>>
>>Reddy VG, Khanna N, Singh N
>>
>>Department of Biochemistry, All India Institute 
>>of Medical Sciences, New Delhi, India
>>
>>Human Papilloma Virus (HPV) is associated in 
>>most instances with cervical cancer. The HPV 
>>oncoproteins target P53 protein for 
>>degradation, leading to deregulation of cell 
>>cycle. We investigated whether stabilization of 
>>P53 in cervical cancer cells, by downregulating 
>>HPV transcription would restore the apoptotic 
>>ability of these cells. Our findings show that 
>>vitamin C downregulates the redox sensitive 
>>transcription factor AP-1 and decreases one of 
>>its transcription targets HPV E6, and 
>>stabilizes P53. This was associated with an 
>>increase in Bax and decrease in Bcl-2 and 
>>telomerase activity. Accumulation of P53 and 
>>its target gene bax then sensitized HeLa cells 
>>to cell-cycle arrest, cell death/apoptosis 
>>induced by cisplatin, and etoposide. Increasing 
>>drug sensitivity of cervical carcinoma cells by 
>>stabilizing P53 using vitamin C is a novel 
>>approach and has potential clinical relevance.
>>
>>
>>
>>
>>--
>><http://www.michaelbalter.com>www.michaelbalter.com
>>
>>******************************************
>>Michael Balter
>>Contributing Correspondent, Science
>><mailto:[log in to unmask]>[log in to unmask]
>>******************************************

-- 
Martha Livingston, Ph.D.
Associate Professor of Health and Society
SUNY College at Old Westbury
Box 210
Old Westbury, New York 11568
(516) 876-2748