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No one special. That's why I didn't add her name. 
Just someone on a list who decided to contact 
Merck directly and ask for information.

Mitchel



At 11:48 AM 2/27/2007, you wrote:
>Hard to debate with "a letter I just received."  Who's it from?
>
>
>
>>Nothing is ever as simple as it fears appears. 
>>For instance, here's a letter I just received:
>>
>>"Here are a couple of things that Merck told 
>>me: girls under 18 were only tracked for 18 
>>months, so no they don't know the long term 
>>effects or the long term efficacy by my way of 
>>thinking. 9,700 women had cervical cancer last 
>>year, 3,700 died. Of those diagnosed, about 30% 
>>of them [1,100] had no known origin (cause) of 
>>the cervical cancer. That means they have no 
>>idea why these women got it and HPV was not 
>>present. Of the rest [2,600] some did indeed 
>>have an HPV causal relationship (no numbers for 
>>how many) but many had a causal relationship 
>>with other viruses. So in terms of numbers, HPV is a pretty weak case."
>>
>>Now, I wouldn't go so far as the writer above 
>>who says that HPV is a pretty weak case. There 
>>clearly is SOME sort of correlation. But, and this has not yet been discussed,
>>
>>1) how many people get genital warts (HPV) each 
>>year, and how many of those people get cervical cancer? and,
>>
>>2) how many cases of cervical cancer are there 
>>each year among people who do not have genital warts?
>>
>>
>>Mitchel Cohen
>>
>>
>>At 07:59 AM 2/27/2007, you wrote:
>>>This paper suggests that Vitamin C might have 
>>>a therapeutic effect in treating cervical 
>>>cancer, although we would want to see clinical 
>>>results that it actually works in practice. If 
>>>an effective vaccine is indeed available, we 
>>>would have few cervical cancer cases to treat in the first place.
>>>
>>>MB
>>>
>>>On 2/27/07, Jonathan Campbell <<mailto:[log in to unmask]>[log in to unmask]> wrote:
>>>FROM: 
>>><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11401473&dopt=Abstract>Biochem 
>>>Biophys Res Commun 2001 (Mar 30);   282 (2): 40915
>>>
>>>Reddy VG, Khanna N, Singh N
>>>
>>>Department of Biochemistry, All India 
>>>Institute of Medical Sciences, New Delhi, India
>>>
>>>Human Papilloma Virus (HPV) is associated in 
>>>most instances with cervical cancer. The HPV 
>>>oncoproteins target P53 protein for 
>>>degradation, leading to deregulation of cell 
>>>cycle. We investigated whether stabilization 
>>>of P53 in cervical cancer cells, by 
>>>downregulating HPV transcription would restore 
>>>the apoptotic ability of these cells. Our 
>>>findings show that vitamin C downregulates the 
>>>redox sensitive transcription factor AP-1 and 
>>>decreases one of its transcription targets HPV 
>>>E6, and stabilizes P53. This was associated 
>>>with an increase in Bax and decrease in Bcl-2 
>>>and telomerase activity. Accumulation of P53 
>>>and its target gene bax then sensitized HeLa 
>>>cells to cell-cycle arrest, cell 
>>>death/apoptosis induced by cisplatin, and 
>>>etoposide. Increasing drug sensitivity of 
>>>cervical carcinoma cells by stabilizing P53 
>>>using vitamin C is a novel approach and has potential clinical relevance.
>>>
>>>
>>>
>>>
>>>--
>>><http://www.michaelbalter.com>www.michaelbalter.com
>>>
>>>******************************************
>>>Michael Balter
>>>Contributing Correspondent, Science
>>><mailto:[log in to unmask]>[log in to unmask]
>>>******************************************
>
>--
>Martha Livingston, Ph.D.
>Associate Professor of Health and Society
>SUNY College at Old Westbury
>Box 210
>Old Westbury, New York 11568
>(516) 876-2748