I'm always suspicious when told it was 3 mos ago in NEJM (or somesuch); it usually turns out to be in JAMA years ago--but we've all been through that. And I think this is another case. Take a look at the following: 1: Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12903-10. Epub 2006 Aug 10. Comment in: Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12661-2. Prenatal exposure to ultrasound waves impacts neuronal migration in mice. Ang ES Jr, Gluncic V, Duque A, Schafer ME, Rakic P. Department of Neurobiology and Kavli Institute for Neuroscience, Yale Medical School, Sterling Hall of Medicine, Room C-318, 333 Cedar Street, New Haven, CT 06510, USA. Neurons of the cerebral neocortex in mammals, including humans, are generated during fetal life in the proliferative zones and then migrate to their final destinations by following an inside-to-outside sequence. The present study examined the effect of ultrasound waves (USW) on neuronal position within the embryonic cerebral cortex in mice. We used a single BrdU injection to label neurons generated at embryonic day 16 and destined for the superficial cortical layers. Our analysis of over 335 animals reveals that, when exposed to USW for a total of 30 min or longer during the period of their migration, a small but statistically significant number of neurons fail to acquire their proper position and remain scattered within inappropriate cortical layers and/or in the subjacent white matter. The magnitude of dispersion of labeled neurons was variable but systematically increased with duration of exposure to USW. These results call for a further investigation in larger and slower-developing brains of non-human primates and continued scrutiny of unnecessarily long prenatal ultrasound exposure. PMID: 16901978 [PubMed - indexed for MEDLINE] Lee Hover Information Developers Boonton Twp., NJ -----Original Message----- From: Medical Libraries Discussion List [mailto:[log in to unmask]] On Behalf Of Document Delivery Sent: Friday, February 09, 2007 2:49 PM To: [log in to unmask] Subject: Re: question Dear Colleagues, Could anyone help in finding the following? One of my editors think there was an article published 3 months ago in either Science or Nature Medicine about ultrasound in pregnant mice has some effect on the fetus brain development. I've searched PubMed Google, Science and Nature Medicine with no luck. Any help with this will be greatly appreciated. Marie Elias, MLS Medical Librarian The Medical Letter, Library 1000 Main Street New Rochelle, NY 10801 Tel: 914-235-0500 Ext. 307 or 334 Fax: 914-235-5079