Dan Koshland was the editor of Science when I first on board in 1991. In my
opinion, he brought considerable discredit to the journal by engaging,
together with Phil Abelson, in a clearly politically motivated attempt to
discredit all research pointing to environmental causes of cancer. On the
positive side, he was instrumental in making Science more international and
less USA-centric, both in the papers it publishes and in its news coverage.

July 28, 2007
 Daniel Koshland Jr., Scientist and Editor, Dies at 87  By JEREMY

Daniel E. Koshland Jr., a biochemist and philanthropist who brought an
unexpectedly puckish tone to Science, the international weekly journal of
research that he edited in the 1980s and '90s, died Monday in Walnut Creek,
Calif. He was 87 and lived in nearby Lafayette, outside Berkeley.

The cause was a stroke, his family said.

From 1985 to 1995, Dr. Koshland shuttled monthly between Science's editorial
offices in Washington and the University of
Berkeley, where he was a professor of molecular and cell biology.

At Science, he helped chronicle innovative developments in medicine,
chemistry, neuroscience and other fields. He expanded the magazine's
coverage of science news, increased the size of its editorial staff and
opened an international bureau in Cambridge, England.

In editorials that he wrote, he also wrestled with ethical questions facing
scientists and inequities in the federal financing of research projects,
which he believed had been skewed against smaller-scale and more daring
experiments often performed by younger investigators.

In some of his lighter writings for Science, Dr. Koshland adopted the alter
ego of Dr. Noitall, a bumptious senior scientist who seemed quite literally
to know it all. In a satirical essay published in 1995, Dr. Noitall demanded
immediate measures to regulate jogging, dieting and the making of New Year's

"People are constrained from smoking, from unsafe sex, from failing to
buckle seat belts," Dr. Koshland wrote. "Why not prevent overblown fantasies
of self-improvement that frequently aren't implemented?"

At Berkeley in the 1980s, Dr. Koshland led an effort to organize the
teaching of biological sciences by grouping a dozen related departments into
three broad categories. A decade-long plan was adopted, including the
construction of two new buildings and the renovation of a third, to house
the newly formed departments of plant biology, integrated biology, and
molecular and cell biology.

A colleague, Robert T. Tjian, a professor of molecular and cell biology at
Berkeley, said a result had been a conservation of resources and "a greater
ease in recruiting faculty and graduate students."

In his own research, Dr. Koshland studied the function of enzymes in the
body and their role in synthesizing proteins. Collaborating with other
scientists, he observed that enzymes can change their shape as they interact
with different molecules, an effect they termed "induced fit."

He later studied bacteria and made observations of their ability to sense
chemicals and even to remember them, in a display of rudimentary memory for
environmental change. In the 1990s, he and others looked at brain cells and
used the brain chemical serotonin to test two cell lines for retention and
loss of memory.

The son of a former president of Levi Strauss and the nephew of another
executive at the company, Dr. Koshland used his considerable inherited
fortune to support science education. In 2004, he gave $25 million to found
a science museum at the National Academy of
Washington. The museum is named for Dr. Koshland's first wife, Marian
Elliott Koshland, an immunologist at Berkeley, who died in 1997.

In an earlier gift, he donated about $23 million to Haverford College in
Pennsylvania to help build a new science center, which is also named for
Marian Koshland.

Daniel Edward Koshland Jr. was born in Manhattan. He earned his
undergraduate degree at Berkeley, then moved to the University of
where he received a doctorate in organic chemistry in 1949.

From 1951 to 1965, he conducted research at Brookhaven National
Long Island, where he was a senior biochemist. He then became a
of biochemistry at Berkeley and remained there for the rest of his career.
He was named a professor emeritus in 1992 and continued his research until
he died.

Dr. Koshland received the National Medal of Science in 1990 and an Albert
Lasker Award for special achievement in medical science in 1998.

He is survived by his wife, Yvonne; two sons, Douglas, of Baltimore, and
James, of Atherton, Calif.; three daughters, Ellen, of Melbourne, Australia;
Gail, of Tucson; and Phyllis, of Sydney, Australia, and Paris; two sisters,
Phyllis Friedman of Hillsborough, Calif., and Francis Geballe of Woodside,
Calif.; nine grandchildren; and one great-grandchild.


Michael Balter
Contributing Correspondent, Science
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