Pesticide link to autism suspected A state study suggests two farm sprays
may raise chances of having a child with the disorder.
By Marla Cone
Times Staff Writer

July 30, 2007

Women who live near California farm fields sprayed with organochlorine
pesticides may be more likely to give birth to children with autism,
according to a study by state health officials to be published today.

The rate of autism among the children of 29 women who lived near the fields
was extremely high, suggesting that exposure to the insecticides in the womb
might have played a role. The study is the first to report a link between
pesticides and the neurological disorder, which affects one in every 150

But the state scientists cautioned that their finding is highly preliminary
because of the small number of women and children involved and lack of
evidence from other studies.

"We want to emphasize that this is exploratory research," said Dr. Mark
Horton, director of the California Department of Public Health. "We have
found very preliminary data that there may be an association. We are in no
way concluding that there is a causal relationship between pesticide
exposure of pregnant women and autism."

The two pesticides implicated are older-generation compounds developed in
the 1950s and used to kill mites, primarily on cotton as well as some
vegetables and other crops. Their volumes have declined substantially in
recent years.

Examining three years of birth records and pesticide data, scientists from
the Public Health Department determined that the Central Valley women lived
within 500 meters, or 547 yards, of fields sprayed with organochlorine
pesticides during their first trimester of pregnancy. Eight of them, or 28%,
had children with autism. Their rate of autism was six times greater than
for mothers who did not live near the fields, the study said.

Susan Kegley, senior scientist of Pesticide Action Network North America, a
San Francisco-based advocacy group, said the report adds to an existing body
of evidence that endosulfan and dicofol, already banned in some countries,
are harmful.

"This is one of the first papers that links use of pesticide to incidence of
a disease, and autism in particular," she said. "The findings are very
strong. This is a sixfold risk factor in comparison to someone who is not
exposed. There aren't too many studies that come out like that."

Even though small numbers of children were involved, "it is still one of
those things that make you sit up and pay attention," she said.

The findings suggest that 7% of autism cases in the Central Valley during
the years studied  1996 through 1998  might have been connected to
exposure to the insecticides drifting off fields into residential areas.
Births during those years were analyzed because children born later might
not yet be diagnosed with autism.

Children with autism spectrum disorders have impaired social and
communication skills. The causes are unknown, but because diagnoses have
been increasing, scientists have been exploring various environmental
factors, including children's vaccines and chemical pollutants.

"The good news is we've used a new research technology to generate
hypotheses and possible associations, so we are making progress in the
battle to get more information" about the cause of autism, Horton said.

The goal of the study was to "systematically explore the general hypothesis
that residential proximity to agricultural pesticide applications during
pregnancy could be associated with autism spectrum disorders in offspring,"
the authors wrote in their study, published online today in the scientific
journal Environmental Health Perspectives.

The scientists collected records of nearly 300,000 children born in the 19
counties of the Sacramento and San Joaquin river valleys. Of those children,
465 had autism. The scientists then compared the addresses during pregnancy
to state records that detailed the location of fields sprayed with several
hundred pesticides.

For most pesticides, no unusual numbers of autism cases were found, but the
exception was a class of compounds called organochlorines. Most, including
DDT, were banned in the United States several decades ago because they were
building up in the environment. Only dicofol and endosulfan remain.

The autism rate was highest for children of those mothers who lived the
closest to the fields and it declined as the distance from the fields

There is no other human or animal evidence that the two chemicals can cause
autism. But both affect nerves and the brain  and cause reproductive
effects and alter hormones in animal tests. In addition, dicofol is a
possible human carcinogen.

The scientists concluded that "the possibility of a connection between
gestational exposure to organochlorine pesticides and autism spectrum
disorders requires further study."

A July report by the state Department of Pesticide Regulation said
endosulfan can spread far from fields via the air and expose the public,
based on air monitoring in Fresno, Monterey and Tulare counties. The agency
is likely to designate endosulfan as a toxic air contaminant soon, and
dicofol could follow. That designation triggers a review by the agency to
see whether steps should be taken to minimize the chemicals drifting off
fields into nearby communities.

Glenn Brank, spokesman for the pesticide agency, said officials there are
"very interested" in the new autism data but say that "more work" on the
potential link is needed before it can carry much weight in assessments of
the chemicals' risks.

The two insecticides are now used much less often than in the years in which
the possible connection to autism was found. As a result, there is less
likelihood that pregnant women are exposed today. Nearly 774,000 pounds were
applied in 1996, compared with 277,000 pounds in 2005, down nearly 64%,
according to state records.

"In the past couple years, the bottom has dropped out of these two," Brank

Insects have built up resistance and cotton farmers have switched to new

The two chemicals are not found in household or yard pesticides. Traces are
found in food, but the study looked only at possible exposure from the air.
The chemicals are used most extensively in Fresno, Kings, Imperial and
Tulare counties. Dicofol is mostly used on cotton, oranges, beans and
walnuts. Endosulfan is used primarily in tomato processing and on lettuce,
alfalfa and cotton crops.

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Michael Balter
Contributing Correspondent, Science
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