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Drug Res (Stuttg). <https://www.ncbi.nlm.nih.gov/pubmed/23526240#> 2013
Jun;63(6):289-92. doi: 10.1055/s-0033-1334963. Epub 2013 Mar 22.
B-vitamin mixture improves the analgesic effect of diclofenac in patients
with osteoarthritis: a double blind study.
Magaña-Villa MC
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Maga%C3%B1a-Villa%20MC%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>
1, Rocha-González HI
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Rocha-Gonz%C3%A1lez%20HI%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>
, Fernández del Valle-Laisequilla C
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Fern%C3%A1ndez%20del%20Valle-Laisequilla%20C%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>
, Granados-Soto V
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Granados-Soto%20V%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>
, Rodríguez-Silverio J
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Rodr%C3%ADguez-Silverio%20J%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>
, Flores-Murrieta FJ
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Flores-Murrieta%20FJ%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>
, Carrasco-Portugal MC
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Carrasco-Portugal%20MC%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>
, Reyes-García JG
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Reyes-Garc%C3%ADa%20JG%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>
.
Author information <https://www.ncbi.nlm.nih.gov/pubmed/23526240#>

   - 1Hospital de Ortopedia Magdalena de las Salinas, Instituto Mexicano
   del Seguro Social, Mexico City, Mexico.

Abstract

According to the high consumption of the mixture of B vitamins and
diclofenac in several countries, this combination has constituted a
frequently used option in pain therapy from inflammatory origin. Although
the evidence obtained from inflammatory pain animal models has shown the
existence of analgesic synergy between diclofenac and the B vitamins
mixture, the corresponding clinical evidence is scarce. A double-blind,
randomized clinical trial study was designed to characterize the analgesic
effect and safety of diclofenac and B vitamins against diclofenac alone in
patients with severe osteoarthritis. Forty eight patients programmed to
total knee arthroplasty with a pain level ≥7 in a 1-10 cm visual analogue
scale were allocated to receive a single intramuscular injection of sodium
diclofenac (75 mg) alone or combined with thiamine (100 mg), pyridoxine
(100 mg) and cyanocobalamin (5 mg), and the pain level was evaluated during
12 h post-injection. Diclofenac+B vitamins mixture showed a superior
analgesic effect during the assessed period and also a better assessment of
the pain relief perception by patients than diclofenac alone. This study
constitutes a clinical support on the improvement of the analgesic effect
of diclofenac by B vitamins in patients with osteoarthritis programmed to
total knee arthroplasty, as a clinical model of inflammatory pain.

© Georg Thieme Verlag KG Stuttgart · New York.
PMID: 23526240 DOI: 10.1055/s-0033-1334963
<https://dx.doi.org/10.1055/s-0033-1334963>
[PubMed - indexed for MEDLINE]


GERARDO GUTIERREZ
MEDICAL LIBRAIAN