 |
 |
Please your help best regards Drug Res (Stuttg). <https://www.ncbi.nlm.nih.gov/pubmed/23526240#> 2013 Jun;63(6):289-92. doi: 10.1055/s-0033-1334963. Epub 2013 Mar 22. B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study. Magaña-Villa MC <https://www.ncbi.nlm.nih.gov/pubmed/?term=Maga%C3%B1a-Villa%20MC%5BAuthor%5D&cauthor=true&cauthor_uid=23526240> 1, Rocha-González HI <https://www.ncbi.nlm.nih.gov/pubmed/?term=Rocha-Gonz%C3%A1lez%20HI%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>, Fernández del Valle-Laisequilla C <https://www.ncbi.nlm.nih.gov/pubmed/?term=Fern%C3%A1ndez%20del%20Valle-Laisequilla%20C%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>, Granados-Soto V <https://www.ncbi.nlm.nih.gov/pubmed/?term=Granados-Soto%20V%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>, Rodríguez-Silverio J <https://www.ncbi.nlm.nih.gov/pubmed/?term=Rodr%C3%ADguez-Silverio%20J%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>, Flores-Murrieta FJ <https://www.ncbi.nlm.nih.gov/pubmed/?term=Flores-Murrieta%20FJ%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>, Carrasco-Portugal MC <https://www.ncbi.nlm.nih.gov/pubmed/?term=Carrasco-Portugal%20MC%5BAuthor%5D&cauthor=true&cauthor_uid=23526240>, Reyes-García JG <https://www.ncbi.nlm.nih.gov/pubmed/?term=Reyes-Garc%C3%ADa%20JG%5BAuthor%5D&cauthor=true&cauthor_uid=23526240> . Author information <https://www.ncbi.nlm.nih.gov/pubmed/23526240#> Abstract According to the high consumption of the mixture of B vitamins and diclofenac in several countries, this combination has constituted a frequently used option in pain therapy from inflammatory origin. Although the evidence obtained from inflammatory pain animal models has shown the existence of analgesic synergy between diclofenac and the B vitamins mixture, the corresponding clinical evidence is scarce. A double-blind, randomized clinical trial study was designed to characterize the analgesic effect and safety of diclofenac and B vitamins against diclofenac alone in patients with severe osteoarthritis. Forty eight patients programmed to total knee arthroplasty with a pain level ≥7 in a 1-10 cm visual analogue scale were allocated to receive a single intramuscular injection of sodium diclofenac (75 mg) alone or combined with thiamine (100 mg), pyridoxine (100 mg) and cyanocobalamin (5 mg), and the pain level was evaluated during 12 h post-injection. Diclofenac+B vitamins mixture showed a superior analgesic effect during the assessed period and also a better assessment of the pain relief perception by patients than diclofenac alone. This study constitutes a clinical support on the improvement of the analgesic effect of diclofenac by B vitamins in patients with osteoarthritis programmed to total knee arthroplasty, as a clinical model of inflammatory pain. © Georg Thieme Verlag KG Stuttgart · New York. PMID:23526240DOI:10.1055/s-0033-1334963 <https://doi.org/10.1055/s-0033-1334963> GERARDO GUTIERREZ MEDICAL LIBRARIAN EDUFARM