Full paper is free online.
This presents another way genetically modified or synthetic organisms could be dangerous as food, since we haven't been eating them for eons for our bodies to have evolved to safely consuming them.
On Wednesday, January 3, 2018 4:47 PM, Glenn Ashton via SynBioCritics <[log in to unmask]> wrote:
A further reason to test
& monitor mRNA events.
Detection of dietetically absorbed
maize-derived microRNAs in pigs
This article has been cited
other articles in PMC.
MicroRNAs are a class of
small RNAs that are important in post-transcriptional gene
regulation in animals and plants. These single-stranded
molecules are widely distributed in organisms and influence
fundamental biological processes. Interestingly, recent
studies have reported that diet-derived plant miRNAs could
regulate mammalian gene expression, and these studies have
broadened our view of cross-kingdom communication. In the
present study, we evaluated miRNA levels in cooked
maize-containing chow diets, and found that plant miRNAs were
resistant to the harsh cooking conditions to a certain extent.
After feeding fresh maize to pigs (7 days), maize-derived
miRNAs could be detected in porcine tissues and serum, and the
authenticity of these plant miRNAs was confirmed by using
oxidization reactions. Furthermore, in vivo and in
vitro experiments demonstrated that dietary maize
miRNAs could cross the gastrointestinal tract and enter the
porcine bloodstream. In the porcine cells, we found that plant
miRNAs are very likely to specifically target their endogenous
porcine mRNAs and influence gene expression in a fashion
similar to that of mammalian miRNAs. Our results indicate that
maize-derived miRNAs can cross the gastrointestinal tract and
present in pigs, and these exogenous miRNAs have the potential
to regulate mammalian gene expression.
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