Nancy O'Brein, sorry to reply to the list but my reply was bounced back (twice. The obesity drug is leptin, the Greek word for thin. It is experimental in mice and is reported in today's issue of Science. Shows great promise for humans. Amgen and two other groups have reached the same conclusion. The drug circulates to the brain and works on the hypothalmus. I can send a newspaper clip if will send me your fax #.