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Authors
  Biarez O.  Sarrut B.  Doreau CG.  Etienne J.
Institution
  Drug Information Center, Central Pharmacy of Hospitals, Paris, France.
Title
  Comparison and evaluation of nine bibliographic databases concerning
  adverse drug reactions.
Source
  DICP.  25(10):1062-5, 1991 Oct.
MeSH Subject Headings
  Comparative Study, *Databases, Bibliographic, *Drugs/ae [Adverse Effects],
  Evaluation Studies, Human, MEDLARS
Abstract
  Few evaluations and statistical comparisons of bibliographic databases
  have been published. As a drug information center, we were particularly
  interested in databases providing references on adverse drug reactions
  (ADRs). Ten drugs were randomly chosen from the 2000 files at our center.
  Nine databases were selected according to the high frequency of references
  concerning ADRs: eight online systems (MEDLINE, BIOSIS, TOXLINE, Iowa Drug
  Information System, PASCAL, EMBASE, PHARMLINE, and International
  Pharmaceutical Abstracts [IPA]), and one Compact Disk Read Only Memory
  (CD-ROM) system (Core MEDLINE). The total number of references, the number
  of references from 1987 to 1989, and the number of relevant references
  from 1987 to 1989 were analyzed using the Friedman two-way ANOVA by ranks.
  The overlap between databases for only one drug, carboplatin, and the
  quality:cost ratio were also studied. Considering the total number of
  references, TOXLINE and EMBASE were significantly superior to IPA,
  PHARMLINE, PASCAL, and Core MEDLINE. For the period 1987-1989, EMBASE was
  significantly superior to PASCAL, IPA, PHARMLINE, and Core MEDLINE with
  regard to total number of references, and significantly superior to
  PASCAL, Core MEDLINE, and IPA with regard to relevance. MEDLINE, TOXLINE,
  and EMBASE had the best quality:cost ratio. EMBASE had the slightest
  overlap of references, with 53 percent of the unique references on
  carboplatin. This comparative evaluation showed that the ability of
  bibliographic databases to provide information on ADRs is dependent on
  both the size and the quality of each database.
 
HTH
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Benoit Thirion                             Phone : (33) 35 08 81 81 ext 63894
Bibliothecaire/Medical Librarian   Fax : (33) 35 08 80 65
Centre Hospitalier Universitaire    E-mail : [log in to unmask]
F 76031 Rouen Cedex                      URL: http://www.chu-rouen.fr
FRANCE
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